The PRSS1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PRSS1, and serine protease 1. This antibody recognizes Human, Mouse, and Rat antigen. The PRSS1 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Function: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
Post-translational Modifications: Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122. Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2' position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
Similarity: Belongs to the peptidase S1 family